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【英文标准名称】:StandardTestMethodforDeterminingCarcinogenicPotentialofVirginBaseOilsinMetalworkingFluids
【原文标准名称】:金属加工液中初榨油致癌可能性测定的标准试验方法
【标准号】:ASTME1687-2004
【标准状态】:现行
【国别】:
【发布日期】:2004
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E34.50
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:致癌;流体;试验
【英文主题词】:baseoils;dermalcarcinogenicity;modifiedAmestest;mutagenicity
【摘要】:ThetestmethodisbasedonamodificationoftheAmesSalmonellamutagenesisassay.Asmodified,thereisgoodcorrelationwithmouseskin-paintingbioassayresultsforsamplesofrawandrefinedlubricatingoilprocessstreams.Mutagenicpotencyinthismodifiedassayandcarcinogenicityintheskin-paintingbioassayalsocorrelatewiththecontentof3to7ringPNAs,whichincludepolynucleararomatichydrocarbonsandtheirheterocyclicanalogs.ThestrengthofthesecorrelationsimpliesthatPNAsaretheprincipalmutagenicandcarcinogenicspeciesintheseoils.SomeofthemethodsthathaveprovidedevidencesupportingthisviewarereferencedinAppendixX1.1.1ThistestmethodcoversamicrobiologicaltestprocedurebasedupontheSalmonellamutagenesisassayofAmesetal()(seealsoMaronetal()).Itcanbeusedasascreeningtechniquetodetectthepresenceofpotentialdermalcarcinogensinvirginbaseoilsusedintheformulationofmetalworkingoils.Personswhoperformthistestshouldbewell-versedintheconductoftheAmestestandconversantwiththephysicalandchemicalpropertiesofpetroleumproducts.1.2Thetestmethodisnotrecommendedasthesoletestingprocedureforoilswhichhaveviscositieslessthan18cSt(90SUS)at40C,orforformulatedmetalworkingfluids.1.3ThevaluesstatedinSIunitsaretoberegardedasthestandard.Thevaluesgiveninparenthesesareprovidedforinformationonly.Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.Sectionprovidesgeneralguidelinesforsafeconductofthistestmethod.
【中国标准分类号】:E34
【国际标准分类号】:
【页数】:8P.;A4
【正文语种】: